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\u0928\u093e\u0915 \u0915\u0947 \u0917\u0902\u0927 \u0916\u0924\u092e \u0939\u094b\u0916\u0947 \u0915\u0947 \u092c\u093e\u0926 \u0905\u0932\u094d\u091c\u093e\u0907\u092e\u0930 \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u092a\u0939\u093f\u0932\u0947 \u0932\u0915\u094d\u0937\u0923 \u0926\u093f\u0916\u093e\u0935\u0947\u0932\u093e?<\/h1>\n

\u0928\u093e\u0915 \u0915\u0947 \u0915\u094b\u0936\u093f\u0915\u093e \u0915\u0947 \u0938\u0930\u0932 \u092c\u093e\u092f\u094b\u092a\u094d\u0938\u0940 \u0938\u0947 \u0905\u0932\u094d\u091c\u093e\u0907\u092e\u0930 \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u092a\u0939\u093f\u0932\u0947 \u091a\u0930\u0923 \u0915\u0947 \u092a\u0924\u093e \u0932\u0917\u093e\u0935\u0932 \u091c\u093e \u0938\u0915\u0924 \u092c\u093e, \u091c\u0947\u0915\u0930\u093e \u0938\u0947 \u092a\u0939\u093f\u0932\u0947 \u0938\u0902\u091c\u094d\u091e\u093e\u0928\u093e\u0924\u094d\u092e\u0915 \u0932\u0915\u094d\u0937\u0923 \u0926\u093f\u0916\u093e\u0908 \u0926\u0947\u0932\u093e. \u0936\u094b\u0927\u0915\u0930\u094d\u0924\u093e \u090f\u0917\u094b \u0905\u0927\u094d\u092f\u092f\u0928 \u092e\u0947\u0902 \u0905\u0932\u0917-\u0905\u0932\u0917 \u091a\u0930\u0923 \u092e\u0947\u0902 \u0930\u0939\u0932 \u0932\u094b\u0917\u0928 \u0915\u0947 \u0928\u093e\u0915 \u0915\u0947 \u0936\u094d\u0932\u0947\u0937\u094d\u092e\u093e \u091d\u093f\u0932\u094d\u0932\u0940 \u0915\u0947 \u0928\u092e\u0942\u0928\u093e \u0915\u0947 \u0935\u093f\u0936\u094d\u0932\u0947\u0937\u0923 \u0915\u0907\u0932\u0947 \u092c\u093e\u0921\u093c\u0947, \u091c\u0947 \u092e\u0947\u0902 \u0938\u094d\u0935\u0938\u094d\u0925 \u0932\u094b\u0917\u0928 \u0915\u0947 \u092d\u0940 \u0936\u093e\u092e\u093f\u0932 \u092c\u093e\u0921\u093c\u0947 \u091c\u0947\u0915\u0930\u093e \u092e\u0947\u0902 \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u091c\u0948\u0935\u093f\u0915 \u092e\u093e\u0930\u094d\u0915\u0930 \u092e\u094c\u091c\u0942\u0926 \u092c\u093e\u0921\u093c\u0947. \u0907\u0939\u094b \u0905\u0927\u094d\u092f\u092f\u0928 \u0926\u0930\u094d\u0936\u093e\u0935\u0947\u0932\u093e \u0915\u093f \u090f\u0939 \u0915\u094d\u0937\u0947\u0924\u094d\u0930, \u091c\u0947 \u0906\u0938\u093e\u0928\u0940 \u0938\u0947 \u092a\u0939\u0941\u0902\u091a \u092f\u094b\u0917\u094d\u092f \u092c\u093e, \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u0935\u093f\u0936\u0947\u0937 \u0938\u0942\u091c\u0928 \u0914\u0930 \u0924\u0902\u0924\u094d\u0930\u093f\u0915\u093e \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0915\u0947 \u0926\u0930\u094d\u0936\u093e\u0935\u0947\u0932\u093e, \u091c\u0947 \u0917\u0948\u0930-\u0906\u0915\u094d\u0930\u093e\u092e\u0915 \u0914\u0930 \u092a\u0939\u093f\u0932\u0947 \u0928\u093f\u0926\u093e\u0928 \u0915\u0947 \u0930\u093e\u0938\u094d\u0924\u093e \u0916\u094b\u0932\u0924 \u092c\u093e.<\/p>\n

\u0928\u093e\u0915 \u0915\u0947 \u0936\u094d\u0932\u0947\u0937\u094d\u092e\u093e \u091d\u093f\u0932\u094d\u0932\u0940, \u091c\u0947 \u0928\u093e\u0915 \u0915\u0947 \u090a\u092a\u0930 \u0935\u093e\u0932\u0947 \u092d\u093e\u0917 \u092e\u0947\u0902 \u0938\u094d\u0925\u093f\u0924 \u092c\u093e, \u092e\u0947\u0902 \u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932 \u0928\u094d\u092f\u0942\u0930\u0949\u0928 \u0939\u094b\u0916\u0947\u0932\u093e \u091c\u0947 \u0938\u0940\u0927\u0947 \u0926\u093f\u092e\u093e\u0917 \u0938\u0947 \u091c\u0941\u0921\u093c\u0932 \u092c\u093e. \u0905\u0932\u094d\u091c\u093e\u0907\u092e\u0930 \u092c\u0940\u092e\u093e\u0930\u0940 \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u0932\u094b\u0917\u0928 \u092e\u0947\u0902 \u090f\u0939 \u0928\u094d\u092f\u0942\u0930\u0949\u0928 \u092e\u0947\u0902 \u0905\u0938\u093e\u092e\u093e\u0928\u094d\u092f \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u0947 \u0938\u0902\u091a\u092f \u0939\u094b\u0916\u0947\u0932\u093e, \u091c\u0947 \u0926\u093f\u092e\u093e\u0917 \u0915\u0947 \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u0928 \u092e\u0947\u0902 \u0926\u0947\u0916\u0932 \u091c\u093e\u0932\u093e. \u0909\u0928\u094d\u0928\u0924 \u0915\u094b\u0936\u093f\u0915\u093e \u0935\u093f\u0936\u094d\u0932\u0947\u0937\u0923 \u0924\u0915\u0928\u0940\u0915 \u0915\u0947 \u0907\u0938\u094d\u0924\u0947\u092e\u093e\u0932 \u0938\u0947, \u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915\u0928 \u090f\u0939 \u0936\u094d\u0932\u0947\u0937\u094d\u092e\u093e \u092e\u0947\u0902 \u0938\u0942\u091c\u0928 \u0914\u0930 \u0928\u094d\u092f\u0942\u0930\u0949\u0928 \u0915\u0947 \u0924\u0928\u093e\u0935 \u0915\u0947 \u092a\u0939\u093f\u0932\u0947 \u0932\u0915\u094d\u0937\u0923 \u0915\u0947 \u092a\u0939\u093f\u091a\u093e\u0928 \u0915\u0907\u0932\u0947 \u092c\u093e\u0921\u093c\u0947, \u092d\u0932\u0947 \u0939\u0940 \u090f\u0917\u094b \u0935\u094d\u092f\u0915\u094d\u0924\u093f \u092e\u0947\u0902 \u0915\u094b\u0908 \u0938\u094d\u092a\u0937\u094d\u091f \u0938\u0902\u091c\u094d\u091e\u093e\u0928\u093e\u0924\u094d\u092e\u0915 \u0935\u093f\u0915\u093e\u0930 \u0928\u093e \u0939\u094b\u0916\u0947 \u0932\u0947\u0915\u093f\u0928 \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u091c\u0948\u0935\u093f\u0915 \u092e\u093e\u0930\u094d\u0915\u0930 \u092e\u094c\u091c\u0942\u0926 \u0939\u094b\u0916\u0947.<\/p>\n

\u0905\u0927\u094d\u092f\u092f\u0928 \u0924\u0940\u0928 \u0938\u092e\u0942\u0939 \u092a\u0930 \u0906\u0927\u093e\u0930\u093f\u0924 \u092c\u093e: \u0938\u094d\u0935\u0938\u094d\u0925 \u0935\u092f\u0938\u094d\u0915, \u0938\u0902\u091c\u094d\u091e\u093e\u0928\u093e\u0924\u094d\u092e\u0915 \u0932\u0915\u094d\u0937\u0923 \u0935\u093e\u0932\u0947 \u092c\u0940\u092e\u093e\u0930\u0940 \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u0932\u094b\u0917, \u0914\u0930 \u090f\u0939 \u0932\u094b\u0917 \u091c\u0947\u0915\u0930\u093e \u092e\u0947\u0902 \u0915\u094b\u0908 \u0932\u0915\u094d\u0937\u0923 \u0928\u093e \u0939\u094b\u0916\u0947 \u0932\u0947\u0915\u093f\u0928 \u0909\u0928\u0915\u0947 \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915-\u092e\u0947\u0930\u0941\u0926\u0902\u0921 \u0926\u094d\u0930\u0935 \u092e\u0947\u0902 \u0905\u0938\u093e\u092e\u093e\u0928\u094d\u092f\u0924\u093e \u0939\u094b\u0916\u0947, \u091c\u0947 \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u092a\u0942\u0930\u094d\u0935-clinical \u091a\u0930\u0923 \u0915\u0947 \u0938\u0902\u0915\u0947\u0924 \u092c\u093e. \u092a\u0930\u093f\u0923\u093e\u092e \u0926\u0930\u094d\u0936\u093e\u0935\u0947\u0932\u093e \u0915\u093f \u0915\u0941\u091b \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e \u0915\u094b\u0936\u093f\u0915\u093e\u0928, \u0935\u093f\u0936\u0947\u0937\u0915\u0930 \u091f\u0940-\u0932\u093f\u092e\u094d\u092b\u094b\u0938\u093e\u0907\u091f, \u0915\u0947 \u0905\u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0938\u0915\u094d\u0930\u093f\u092f\u0924\u093e \u0914\u0930 \u092e\u093e\u0907\u0915\u094d\u0930\u094b\u0917\u094d\u0932\u093f\u092f\u093e \u0915\u094b\u0936\u093f\u0915\u093e\u0928 \u092e\u0947\u0902 \u0938\u0942\u091c\u0928 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0930\u092e \u092e\u0947\u0902 \u0935\u0943\u0926\u094d\u0927\u093f \u0939\u094b\u0916\u0947\u0932\u093e. \u090f\u0939 \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928, \u091c\u0947 \u092a\u0942\u0930\u094d\u0935-clinical \u091a\u0930\u0923 \u0938\u0947 \u0939\u0940 \u0926\u0947\u0916\u0932 \u091c\u093e\u0932\u093e, \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u092a\u094d\u0930\u0917\u0924\u093f \u0915\u0947 \u0938\u093e\u0925 \u0914\u0930 \u092c\u0922\u093c\u0924 \u091c\u093e\u0932\u093e.<\/p>\n

\u0917\u0902\u0927 \u0915\u0947 \u092a\u0924\u093e \u0932\u0917\u093e\u0935\u0947 \u0935\u093e\u0932\u0947 \u0928\u094d\u092f\u0942\u0930\u0949\u0928 \u092e\u0947\u0902 \u092d\u0940 \u0906\u0923\u0935\u093f\u0915 \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0926\u0947\u0916\u0932 \u0917\u0947\u0932 \u092c\u093e. \u0909\u0926\u093e\u0939\u0930\u0923 \u0915\u0947 \u0924\u094c\u0930 \u092a\u0930, \u0938\u0942\u091c\u0928 \u0914\u0930 \u0911\u0915\u094d\u0938\u0940\u0921\u0947\u091f\u093f\u0935 \u0924\u0928\u093e\u0935 \u0938\u0947 \u091c\u0941\u0921\u093c\u0932 \u091c\u0940\u0928 \u0915\u0947 \u0905\u092d\u093f\u0935\u094d\u092f\u0915\u094d\u0924\u093f \u092e\u0947\u0902 \u0935\u0943\u0926\u094d\u0927\u093f \u0939\u094b\u0916\u0947\u0932\u093e, \u091c\u092c\u0915\u093f \u0938\u0941\u0930\u0915\u094d\u0937\u093e\u0924\u094d\u092e\u0915 \u091c\u0940\u0928 \u0915\u0947 \u0905\u092d\u093f\u0935\u094d\u092f\u0915\u094d\u0924\u093f \u092e\u0947\u0902 \u0915\u092e\u0940 \u0906\u0932 \u092c\u093e. \u090f\u0939 \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0928\u094d\u092f\u0942\u0930\u0949\u0928 \u0914\u0930 \u092a\u094d\u0930\u0924\u093f\u0930\u0915\u094d\u0937\u093e \u0915\u094b\u0936\u093f\u0915\u093e\u0928 \u0915\u0947 \u092c\u0940\u091a \u0938\u0902\u091a\u093e\u0930 \u092e\u0947\u0902 \u0917\u0921\u093c\u092c\u0921\u093c\u0940 \u0915\u0947 \u0938\u0902\u0915\u0947\u0924 \u0926\u0947\u0932\u093e, \u091c\u0947 \u0928\u094d\u092f\u0942\u0930\u0949\u0928 \u0915\u0947 \u0915\u094d\u0937\u092f \u092e\u0947\u0902 \u092f\u094b\u0917\u0926\u093e\u0928 \u0926\u0947 \u0938\u0915\u0924 \u092c\u093e.<\/p>\n

\u0928\u093e\u0915 \u0915\u0947 \u0928\u092e\u0942\u0928\u093e\u0928 \u0915\u0947 \u0935\u093f\u0936\u094d\u0932\u0947\u0937\u0923 \u0938\u0947 \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u092a\u094d\u0930\u0917\u0924\u093f \u0915\u0947 \u091f\u094d\u0930\u0948\u0915 \u0915\u0907\u0932 \u091c\u093e \u0938\u0915\u0924 \u092c\u093e \u0914\u0930 \u0938\u0902\u092d\u093e\u0935\u093f\u0924 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0932\u0915\u094d\u0937\u094d\u092f \u0915\u0947 \u092a\u0939\u093f\u091a\u093e\u0928 \u0915\u0907\u0932 \u091c\u093e \u0938\u0915\u0924 \u092c\u093e. \u090f\u0939 \u0926\u0943\u0937\u094d\u091f\u093f\u0915\u094b\u0923 \u0905\u0932\u094d\u091c\u093e\u0907\u092e\u0930 \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u092a\u0939\u093f\u0932\u0947 \u0924\u0902\u0924\u094d\u0930 \u0915\u0947 \u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u0947 \u090f\u0917\u094b \u0935\u094d\u092f\u093e\u0935\u0939\u093e\u0930\u093f\u0915 \u0924\u0930\u0940\u0915\u093e \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924 \u092c\u093e, \u091c\u0947 \u0905\u0915\u094d\u0938\u0930 \u091c\u0940\u0935\u093f\u0924 \u0926\u093f\u092e\u093e\u0917 \u092e\u0947\u0902 \u0926\u0947\u0916\u0932 \u092e\u0947\u0902 \u092e\u0941\u0936\u094d\u0915\u093f\u0932 \u0939\u094b\u0916\u0947\u0932\u093e. \u090f\u0939 \u0935\u093f\u0927\u093f \u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u0928, \u091c\u0948\u0938\u0947 \u0930\u0915\u094d\u0924 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092f\u093e \u0907\u092e\u0947\u091c\u093f\u0902\u0917 \u092a\u0930\u0940\u0915\u094d\u0937\u0923, \u0915\u0947 \u092a\u0942\u0930\u0915 \u0939\u094b \u0938\u0915\u0924 \u092c\u093e \u0924\u093e\u0915\u093f \u0930\u094b\u0917\u0940 \u0915\u0947 \u0928\u093f\u0926\u093e\u0928 \u0914\u0930 \u0928\u093f\u0917\u0930\u093e\u0928\u0940 \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 \u0939\u094b \u0938\u0915\u0947.<\/p>\n

\u0938\u093e\u0930\u093e\u0902\u0936 \u092e\u0947\u0902, \u0928\u093e\u0915 \u0915\u0947 \u0936\u094d\u0932\u0947\u0937\u094d\u092e\u093e \u091d\u093f\u0932\u094d\u0932\u0940 \u0926\u093f\u092e\u093e\u0917 \u0915\u0947 \u090a\u092a\u0930 \u090f\u0917\u094b \u0916\u093f\u0921\u093c\u0915\u0940 \u0915\u0947 \u0924\u0930\u0939 \u0915\u093e\u092e \u0915\u0930\u0924 \u092c\u093e, \u091c\u0947 \u0932\u0915\u094d\u0937\u0923 \u0926\u093f\u0916\u093e\u0908 \u0926\u0947\u0932\u093e \u0938\u0947 \u092c\u0939\u0941\u0924 \u092a\u0939\u093f\u0932\u0947 \u0939\u0940 \u0930\u094b\u0917 \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e \u0915\u0947 \u0926\u0930\u094d\u0936\u093e\u0935\u0947\u0932\u093e. \u090f\u0939 \u0916\u094b\u091c \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u092a\u094d\u0930\u092c\u0902\u0927\u0928 \u092e\u0947\u0902 \u0915\u094d\u0930\u093e\u0902\u0924\u093f \u0932\u093e \u0938\u0915\u0924 \u092c\u093e, \u091c\u0947 \u092a\u0939\u093f\u0932\u0947 \u0914\u0930 \u092c\u0947\u0939\u0924\u0930 \u0932\u0915\u094d\u0937\u093f\u0924 \u0939\u0938\u094d\u0924\u0915\u094d\u0937\u0947\u092a \u0915\u0947 \u0905\u0928\u0941\u092e\u0924\u093f \u0926\u0947\u0932\u093e.<\/p>\n

\n

Attributions et sources<\/h2>\n

Origine de l\u2019\u00e9tude<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41467-026-70099-7<\/a><\/p>\n

Titre\u00a0:<\/strong> Olfactory cleft biopsy analysis of Alzheimer\u2019s disease pathobiology across disease stages<\/p>\n

Revue : <\/strong> Nature Communications<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Vincent M. D\u2019Anniballe; Sarah Kim; John B. Finlay; Michael Wang; Tiffany Ko; Sheng Luo; Heather E. Whitson; Kim G. Johnson; Bradley J. Goldstein<\/p>\n","protected":false},"excerpt":{"rendered":"

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