M\u1ed9t sinh thi\u1ebft \u0111\u01a1n gi\u1ea3n t\u1eeb c\u00e1c t\u1ebf b\u00e0o m\u0169i c\u00f3 th\u1ec3 gi\u00fap ph\u00e1t hi\u1ec7n c\u00e1c giai \u0111o\u1ea1n \u0111\u1ea7u ti\u00ean c\u1ee7a b\u1ec7nh Alzheimer, l\u00e2u tr\u01b0\u1edbc khi xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u1eadn th\u1ee9c. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e2n t\u00edch c\u00e1c m\u1eabu l\u1ea5y t\u1eeb ni\u00eam m\u1ea1c kh\u1ee9u gi\u00e1c c\u1ee7a nh\u1eefng ng\u01b0\u1eddi \u1edf c\u00e1c giai \u0111o\u1ea1n kh\u00e1c nhau c\u1ee7a b\u1ec7nh, bao g\u1ed3m c\u1ea3 nh\u1eefng c\u00e1 nh\u00e2n kh\u1ecfe m\u1ea1nh nh\u01b0ng c\u00f3 c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc b\u00e1o tr\u01b0\u1edbc. C\u00f4ng tr\u00ecnh c\u1ee7a h\u1ecd cho th\u1ea5y v\u00f9ng n\u00e0y, d\u1ec5 ti\u1ebfp c\u1eadn, ph\u1ea3n \u00e1nh nh\u1eefng thay \u0111\u1ed5i vi\u00eam v\u00e0 th\u1ea7n kinh \u0111\u1eb7c tr\u01b0ng c\u1ee7a b\u1ec7nh, m\u1edf ra con \u0111\u01b0\u1eddng cho ch\u1ea9n \u0111o\u00e1n s\u1edbm v\u00e0 kh\u00f4ng x\u00e2m l\u1ea5n.<\/p>\n
Ni\u00eam m\u1ea1c kh\u1ee9u gi\u00e1c, n\u1eb1m \u1edf ph\u1ea7n tr\u00ean c\u1ee7a m\u0169i, ch\u1ee9a c\u00e1c n\u01a1-ron c\u1ea3m gi\u00e1c k\u1ebft n\u1ed1i tr\u1ef1c ti\u1ebfp v\u1edbi n\u00e3o. \u1ede nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh Alzheimer, c\u00e1c n\u01a1-ron n\u00e0y t\u00edch l\u0169y c\u00e1c protein b\u1ea5t th\u01b0\u1eddng t\u01b0\u01a1ng t\u1ef1 nh\u01b0 nh\u1eefng protein \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y trong c\u00e1c v\u00f9ng n\u00e3o b\u1ecb \u1ea3nh h\u01b0\u1edfng. B\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt ph\u00e2n t\u00edch t\u1ebf b\u00e0o ti\u00ean ti\u1ebfn, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u00e1c d\u1ea5u hi\u1ec7u vi\u00eam v\u00e0 c\u0103ng th\u1eb3ng th\u1ea7n kinh s\u1edbm trong ni\u00eam m\u1ea1c n\u00e0y, ngay c\u1ea3 \u1edf nh\u1eefng c\u00e1 nh\u00e2n kh\u00f4ng c\u00f3 r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c r\u00f5 r\u00e0ng nh\u01b0ng mang c\u00e1c d\u1ea5u \u1ea5n sinh h\u1ecdc c\u1ee7a b\u1ec7nh.<\/p>\n
Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n tr\u00ean ba nh\u00f3m: ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kh\u1ecfe m\u1ea1nh, nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh c\u00f3 tri\u1ec7u ch\u1ee9ng nh\u1eadn th\u1ee9c, v\u00e0 nh\u1eefng ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng nh\u01b0ng c\u00f3 b\u1ea5t th\u01b0\u1eddng trong d\u1ecbch n\u00e3o t\u1ee7y, d\u1ea5u hi\u1ec7u c\u1ee7a giai \u0111o\u1ea1n ti\u1ec1n l\u00e2m s\u00e0ng. K\u1ebft qu\u1ea3 cho th\u1ea5y s\u1ef1 ho\u1ea1t h\u00f3a b\u1ea5t th\u01b0\u1eddng c\u1ee7a m\u1ed9t s\u1ed1 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c t\u1ebf b\u00e0o lympho T, c\u0169ng nh\u01b0 s\u1ef1 gia t\u0103ng c\u00e1c ch\u01b0\u01a1ng tr\u00ecnh vi\u00eam trong c\u00e1c t\u1ebf b\u00e0o ki\u1ec3u vi m\u00f4. Nh\u1eefng thay \u0111\u1ed5i n\u00e0y, \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y ngay t\u1eeb giai \u0111o\u1ea1n ti\u1ec1n l\u00e2m s\u00e0ng, tr\u1edf n\u00ean nghi\u00eam tr\u1ecdng h\u01a1n khi b\u1ec7nh ti\u1ebfn tri\u1ec3n.<\/p>\n
C\u00e1c n\u01a1-ron kh\u1ee9u gi\u00e1c, ch\u1ecbu tr\u00e1ch nhi\u1ec7m ph\u00e1t hi\u1ec7n m\u00f9i, c\u0169ng cho th\u1ea5y nh\u1eefng thay \u0111\u1ed5i ph\u00e2n t\u1eed. V\u00ed d\u1ee5, bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c gen li\u00ean quan \u0111\u1ebfn vi\u00eam v\u00e0 c\u0103ng th\u1eb3ng oxy h\u00f3a t\u0103ng l\u00ean, trong khi bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c gen b\u1ea3o v\u1ec7 l\u1ea1i gi\u1ea3m. Nh\u1eefng thay \u0111\u1ed5i n\u00e0y g\u1ee3i \u00fd m\u1ed9t s\u1ef1 giao ti\u1ebfp b\u1ecb r\u1ed1i lo\u1ea1n gi\u1eefa c\u00e1c n\u01a1-ron v\u00e0 c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch, m\u1ed9t c\u01a1 ch\u1ebf c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n v\u00e0o s\u1ef1 tho\u00e1i h\u00f3a th\u1ea7n kinh.<\/p>\n
Ph\u00e2n t\u00edch c\u00e1c m\u1eabu m\u0169i do \u0111\u00f3 cho ph\u00e9p theo d\u00f5i s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh v\u00e0 x\u00e1c \u0111\u1ecbnh c\u00e1c m\u1ee5c ti\u00eau ti\u1ec1m n\u0103ng cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb. Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn n\u00e0y cung c\u1ea5p m\u1ed9t c\u00e1ch th\u1ee9c thu\u1eadn ti\u1ec7n \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c c\u01a1 ch\u1ebf s\u1edbm c\u1ee7a b\u1ec7nh Alzheimer, th\u01b0\u1eddng kh\u00f3 quan s\u00e1t trong n\u00e3o s\u1ed1ng. N\u00f3 c\u0169ng c\u00f3 th\u1ec3 b\u1ed5 sung cho c\u00e1c x\u00e9t nghi\u1ec7m hi\u1ec7n t\u1ea1i, nh\u01b0 x\u00e9t nghi\u1ec7m m\u00e1u ho\u1eb7c c\u00e1c x\u00e9t nghi\u1ec7m h\u00ecnh \u1ea3nh, \u0111\u1ec3 tinh ch\u1ec9nh ch\u1ea9n \u0111o\u00e1n v\u00e0 theo d\u00f5i b\u1ec7nh nh\u00e2n.<\/p>\n
T\u00f3m l\u1ea1i, ni\u00eam m\u1ea1c kh\u1ee9u gi\u00e1c ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t c\u1eeda s\u1ed5 v\u00e0o n\u00e3o b\u1ed9, ti\u1ebft l\u1ed9 c\u00e1c qu\u00e1 tr\u00ecnh b\u1ec7nh l\u00fd l\u00e2u tr\u01b0\u1edbc khi c\u00e1c tri\u1ec7u ch\u1ee9ng xu\u1ea5t hi\u1ec7n. Ph\u00e1t hi\u1ec7n n\u00e0y c\u00f3 th\u1ec3 thay \u0111\u1ed5i c\u00e1ch qu\u1ea3n l\u00fd b\u1ec7nh, cho ph\u00e9p can thi\u1ec7p s\u1edbm h\u01a1n v\u00e0 nh\u1eafm m\u1ee5c ti\u00eau t\u1ed1t h\u01a1n.<\/p>\n
DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41467-026-70099-7<\/a><\/p>\n Titre\u00a0:<\/strong> Olfactory cleft biopsy analysis of Alzheimer\u2019s disease pathobiology across disease stages<\/p>\n Revue : <\/strong> Nature Communications<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Vincent M. D\u2019Anniballe; Sarah Kim; John B. Finlay; Michael Wang; Tiffany Ko; Sheng Luo; Heather E. Whitson; Kim G. Johnson; Bradley J. Goldstein<\/p>\n","protected":false},"excerpt":{"rendered":" M\u1ea5t kh\u1ee9u gi\u00e1c c\u00f3 ti\u1ebft l\u1ed9 nh\u1eefng d\u1ea5u hi\u1ec7u \u0111\u1ea7u ti\u00ean c\u1ee7a b\u1ec7nh Alzheimer? M\u1ed9t sinh thi\u1ebft \u0111\u01a1n gi\u1ea3n t\u1eeb c\u00e1c t\u1ebf b\u00e0o m\u0169i c\u00f3 th\u1ec3 gi\u00fap ph\u00e1t hi\u1ec7n c\u00e1c giai \u0111o\u1ea1n \u0111\u1ea7u ti\u00ean c\u1ee7a b\u1ec7nh Alzheimer, l\u00e2u tr\u01b0\u1edbc khi xu\u1ea5t hi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u1eadn th\u1ee9c. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e2n t\u00edch c\u00e1c… Continue reading M\u1ea5t kh\u1ee9u gi\u00e1c c\u00f3 ti\u1ebft l\u1ed9 nh\u1eefng d\u1ea5u hi\u1ec7u \u0111\u1ea7u ti\u00ean c\u1ee7a b\u1ec7nh Alzheimer?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-15","post","type-post","status-publish","format-standard","hentry","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/posts\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":1,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/posts\/15\/revisions"}],"predecessor-version":[{"id":16,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/posts\/15\/revisions\/16"}],"wp:attachment":[{"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/media?parent=15"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/categories?post=15"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/tags?post=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}