{"id":17,"date":"2026-06-16T10:49:09","date_gmt":"2026-06-16T08:49:09","guid":{"rendered":"https:\/\/crseh.com\/vi\/2026\/06\/16\/lao-hoa-te-bao-trong-mau-tiet-lo-nguy-co-mac-benh\/"},"modified":"2026-06-16T10:50:56","modified_gmt":"2026-06-16T08:50:56","slug":"lao-hoa-te-bao-trong-mau-tiet-lo-nguy-co-mac-benh","status":"publish","type":"post","link":"https:\/\/crseh.com\/vi\/2026\/06\/16\/lao-hoa-te-bao-trong-mau-tiet-lo-nguy-co-mac-benh\/","title":{"rendered":"L\u00e3o h\u00f3a t\u1ebf b\u00e0o trong m\u00e1u ti\u1ebft l\u1ed9 nguy c\u01a1 m\u1eafc b\u1ec7nh"},"content":{"rendered":"

\"L\u00e3o“`html<\/p>\n

L\u00e3o h\u00f3a t\u1ebf b\u00e0o trong m\u00e1u ti\u1ebft l\u1ed9 nguy c\u01a1 m\u1eafc b\u1ec7nh<\/h1>\n

Ph\u00e2n t\u00edch s\u00e2u r\u1ed9ng h\u01a1n 7.000 protein huy\u1ebft t\u01b0\u01a1ng \u1edf 60.000 ng\u01b0\u1eddi \u0111\u00e3 cho ph\u00e9p ph\u00e1t tri\u1ec3n c\u00e1c m\u00f4 h\u00ecnh c\u00f3 th\u1ec3 \u01b0\u1edbc t\u00ednh tu\u1ed5i sinh h\u1ecdc c\u1ee7a h\u01a1n 40 lo\u1ea1i t\u1ebf b\u00e0o, t\u1eeb t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u1ebfn t\u1ebf b\u00e0o c\u01a1 v\u00e0 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch. K\u1ebft qu\u1ea3 cho th\u1ea5y l\u00e3o h\u00f3a kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o theo c\u00f9ng m\u1ed9t c\u00e1ch: kho\u1ea3ng 20 \u0111\u1ebfn 25% c\u00e1 nh\u00e2n c\u00f3 l\u00e3o h\u00f3a nhanh \u1edf m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o duy nh\u1ea5t, trong khi 1 \u0111\u1ebfn 3% c\u00f3 \u00edt nh\u1ea5t m\u01b0\u1eddi lo\u1ea1i t\u1ebf b\u00e0o b\u1ecb \u1ea3nh h\u01b0\u1edfng.<\/p>\n

C\u00e1c d\u1ea5u hi\u1ec7u l\u00e3o h\u00f3a t\u1ebf b\u00e0o n\u00e0y c\u00f3 m\u1ed1i li\u00ean h\u1ec7 ch\u1eb7t ch\u1ebd v\u1edbi s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a b\u1ec7nh t\u1eadt v\u00e0 t\u1ef7 l\u1ec7 t\u1eed vong trong v\u00f2ng 15 n\u0103m. V\u00ed d\u1ee5, nh\u1eefng ng\u01b0\u1eddi mang gen APOE4, \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn l\u00e0 l\u00e0m t\u0103ng nguy c\u01a1 m\u1eafc b\u1ec7nh Alzheimer, th\u1ec3 hi\u1ec7n l\u00e3o h\u00f3a nhanh \u1edf t\u1ebf b\u00e0o h\u00ecnh sao (astrocytes), m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o n\u00e3o, nh\u01b0ng l\u1ea1i c\u00f3 s\u1ef1 tr\u1ebb h\u00f3a t\u01b0\u01a1ng \u0111\u1ed1i \u1edf \u0111\u1ea1i th\u1ef1c b\u00e0o (macrophages), c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch. Ng\u01b0\u1ee3c l\u1ea1i, nh\u1eefng ng\u01b0\u1eddi mang gen APOE2 cho th\u1ea5y m\u1ed9t h\u1ed3 s\u01a1 \u0111\u1ed1i l\u1eadp, v\u1edbi t\u1ebf b\u00e0o h\u00ecnh sao tr\u1ebb h\u01a1n v\u00e0 \u0111\u1ea1i th\u1ef1c b\u00e0o gi\u00e0 h\u01a1n. Nh\u1eefng kh\u00e1c bi\u1ec7t n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3i th\u00edch b\u1edfi c\u00e1c c\u01a1 ch\u1ebf ti\u1ebfn h\u00f3a, n\u01a1i gen APOE4, b\u1eb1ng c\u00e1ch t\u0103ng c\u01b0\u1eddng s\u1ef1 c\u1ea3nh gi\u00e1c mi\u1ec5n d\u1ecbch, \u0111\u00e3 mang l\u1ea1i l\u1ee3i th\u1ebf s\u1ed1ng s\u00f3t tr\u01b0\u1edbc c\u00e1c m\u1ea7m b\u1ec7nh trong qu\u00e1 kh\u1ee9, v\u1edbi c\u00e1i gi\u00e1 l\u00e0 l\u00e3o h\u00f3a nhanh h\u01a1n c\u1ee7a n\u00e3o b\u1ed9.<\/p>\n

L\u00e3o h\u00f3a c\u1ef1c \u0111\u1ed9 c\u1ee7a t\u1ebf b\u00e0o h\u00ecnh sao l\u00e0m t\u0103ng g\u1ea5p ba nguy c\u01a1 m\u1eafc b\u1ec7nh Alzheimer \u1edf nh\u1eefng ng\u01b0\u1eddi c\u00f3 hai b\u1ea3n sao c\u1ee7a gen APOE4, trong khi s\u1ef1 tr\u1ebb h\u00f3a c\u1ee7a c\u00e1c t\u1ebf b\u00e0o n\u00e0y l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 nguy c\u01a1 n\u00e0y. T\u01b0\u01a1ng t\u1ef1, l\u00e3o h\u00f3a \u0111\u00e1ng k\u1ec3 c\u1ee7a t\u1ebf b\u00e0o c\u01a1 x\u01b0\u01a1ng l\u00e0m t\u0103ng g\u1ea5p 12,7 l\u1ea7n nguy c\u01a1 m\u1eafc b\u1ec7nh x\u01a1 c\u1ee9ng teo c\u01a1 m\u1ed9t b\u00ean (ALS), m\u1ed9t b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh nghi\u00eam tr\u1ecdng. \u1ede nh\u1eefng ng\u01b0\u1eddi h\u00fat thu\u1ed1c, l\u00e3o h\u00f3a nhanh c\u1ee7a t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 h\u00f4 h\u1ea5p l\u00e0m t\u0103ng 58% nguy c\u01a1 ung th\u01b0 ph\u1ed5i so v\u1edbi vi\u1ec7c ch\u1ec9 h\u00fat thu\u1ed1c.<\/p>\n

C\u00e1c d\u1ea5u hi\u1ec7u l\u00e3o h\u00f3a t\u1ebf b\u00e0o c\u0169ng cho ph\u00e9p d\u1ef1 \u0111o\u00e1n c\u00e1c b\u1ec7nh kh\u00e1c. L\u00e3o h\u00f3a c\u1ef1c \u0111\u1ed9 c\u1ee7a t\u1ebf b\u00e0o ph\u1ebf nang lo\u1ea1i 2, \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c s\u1eeda ch\u1eefa ph\u1ed5i, c\u00f3 li\u00ean quan \u0111\u1ebfn nguy c\u01a1 t\u0103ng cao m\u1eafc ung th\u01b0 ph\u1ed5i, ngay c\u1ea3 \u1edf nh\u1eefng ng\u01b0\u1eddi kh\u00f4ng h\u00fat thu\u1ed1c. \u0110\u1ed1i v\u1edbi b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2, l\u00e3o h\u00f3a \u0111\u00e1ng k\u1ec3 c\u1ee7a c\u00e1c t\u1ebf b\u00e0o d\u00f2ng tu\u1ef7, li\u00ean quan \u0111\u1ebfn vi\u00eam nhi\u1ec5m, l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 nguy c\u01a1, ngay c\u1ea3 khi kh\u00f4ng c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 truy\u1ec1n th\u1ed1ng nh\u01b0 n\u1ed3ng \u0111\u1ed9 \u0111\u01b0\u1eddng trong m\u00e1u cao.<\/p>\n

Nghi\u00ean c\u1ee9u c\u0169ng ti\u1ebft l\u1ed9 r\u1eb1ng l\u1ed1i s\u1ed1ng \u1ea3nh h\u01b0\u1edfng tr\u1ef1c ti\u1ebfp \u0111\u1ebfn l\u00e3o h\u00f3a t\u1ebf b\u00e0o. Nh\u1eefng c\u00e1 nh\u00e2n c\u00f3 l\u1ed1i s\u1ed1ng l\u00e0nh m\u1ea1nh, \u0111\u1eb7c tr\u01b0ng b\u1edfi kh\u00f4ng h\u00fat thu\u1ed1c, u\u1ed1ng r\u01b0\u1ee3u \u0111i\u1ec1u \u0111\u1ed9, ch\u1ec9 s\u1ed1 kh\u1ed1i c\u01a1 th\u1ec3 b\u00ecnh th\u01b0\u1eddng, ho\u1ea1t \u0111\u1ed9ng th\u1ec3 ch\u1ea5t th\u01b0\u1eddng xuy\u00ean v\u00e0 ng\u1ee7 \u0111\u1ee7 gi\u1ea5c, c\u00f3 c\u00e1c t\u1ebf b\u00e0o nh\u00ecn chung tr\u1ebb h\u01a1n. Ng\u01b0\u1ee3c l\u1ea1i, nh\u1eefng ng\u01b0\u1eddi k\u1ebft h\u1ee3p h\u00fat thu\u1ed1c v\u00e0 b\u00e9o ph\u00ec th\u1ec3 hi\u1ec7n l\u00e3o h\u00f3a nhanh \u1edf nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o.<\/p>\n

G\u00e1nh n\u1eb7ng t\u00edch l\u0169y c\u1ee7a l\u00e3o h\u00f3a t\u1ebf b\u00e0o c\u00f3 t\u00e1c \u0111\u1ed9ng l\u1edbn \u0111\u1ebfn s\u1ef1 s\u1ed1ng s\u00f3t. Nh\u1eefng ng\u01b0\u1eddi c\u00f3 h\u01a1n 20 lo\u1ea1i t\u1ebf b\u00e0o l\u00e3o h\u00f3a nhanh c\u00f3 t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t sau 15 n\u0103m kho\u1ea3ng 34%, so v\u1edbi 90% \u1edf nh\u1eefng ng\u01b0\u1eddi c\u00f3 t\u1ebf b\u00e0o l\u00e3o h\u00f3a b\u00ecnh th\u01b0\u1eddng. Ng\u01b0\u1ee3c l\u1ea1i, c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch ho\u1eb7c th\u1ea7n kinh tr\u1ebb h\u00f3a gi\u00fap c\u1ea3i thi\u1ec7n tu\u1ed5i th\u1ecd. M\u1ed9t \u0111i\u1ec3m s\u1ed1 nguy c\u01a1 \u0111a t\u1ebf b\u00e0o \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n \u0111\u1ec3 ph\u00e2n t\u1ea7ng nguy c\u01a1 t\u1eed vong, ch\u1ee9ng minh kh\u1ea3 n\u0103ng d\u1ef1 \u0111o\u00e1n m\u1ea1nh m\u1ebd qua c\u00e1c n\u1ec1n t\u1ea3ng ph\u00e2n t\u00edch protein kh\u00e1c nhau.<\/p>\n

Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y mang l\u1ea1i m\u1ed9t c\u00e1ch m\u1edbi \u0111\u1ec3 hi\u1ec3u v\u1ec1 l\u00e3o h\u00f3a \u1edf con ng\u01b0\u1eddi \u1edf c\u1ea5p \u0111\u1ed9 t\u1ebf b\u00e0o. Ch\u00fang m\u1edf ra con \u0111\u01b0\u1eddng cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p c\u00e1 nh\u00e2n h\u00f3a \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 nguy c\u01a1 m\u1eafc b\u1ec7nh v\u00e0 x\u00e1c \u0111\u1ecbnh c\u00e1c m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng, b\u1eb1ng c\u00e1ch nh\u1eafm m\u1ee5c ti\u00eau c\u1ee5 th\u1ec3 v\u00e0o c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o d\u1ec5 b\u1ecb t\u1ed5n th\u01b0\u01a1ng nh\u1ea5t. L\u00e3o h\u00f3a kh\u00f4ng c\u00f2n \u0111\u01b0\u1ee3c xem nh\u01b0 m\u1ed9t qu\u00e1 tr\u00ecnh \u0111\u1ed3ng nh\u1ea5t, m\u00e0 nh\u01b0 m\u1ed9t b\u1ee9c tranh gh\u00e9p c\u1ee7a c\u00e1c qu\u1ef9 \u0111\u1ea1o t\u1ebf b\u00e0o ri\u00eang bi\u1ec7t, m\u1ed7i qu\u1ef9 \u0111\u1ea1o \u0111\u00f3ng g\u00f3p kh\u00e1c nhau v\u00e0o s\u1ee9c kh\u1ecfe v\u00e0 b\u1ec7nh t\u1eadt.<\/p>\n

“`<\/p>\n

\n

Attributions et sources<\/h2>\n

Origine de l\u2019\u00e9tude<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41591-026-04446-y<\/a><\/p>\n

Titre\u00a0:<\/strong> Plasma proteomic signatures of cellular aging predict human disease<\/p>\n

Revue : <\/strong> Nature Medicine<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Daisy Yi Ding; Veronica Augustina Bot; Kenneth L. Chen; James W. Groves; R\u00f3bert P\u00e1lovics; Daisuke Masuda; Amelia Farinas; Hamilton Se-Hwee Oh; Viktoria Wagner; Nannan Lu; ; Carlos Cruchaga; Alina Isakova; Jonathan M. Schott; Tony Wyss-Coray<\/p>\n","protected":false},"excerpt":{"rendered":"

“`html L\u00e3o h\u00f3a t\u1ebf b\u00e0o trong m\u00e1u ti\u1ebft l\u1ed9 nguy c\u01a1 m\u1eafc b\u1ec7nh Ph\u00e2n t\u00edch s\u00e2u r\u1ed9ng h\u01a1n 7.000 protein huy\u1ebft t\u01b0\u01a1ng \u1edf 60.000 ng\u01b0\u1eddi \u0111\u00e3 cho ph\u00e9p ph\u00e1t tri\u1ec3n c\u00e1c m\u00f4 h\u00ecnh c\u00f3 th\u1ec3 \u01b0\u1edbc t\u00ednh tu\u1ed5i sinh h\u1ecdc c\u1ee7a h\u01a1n 40 lo\u1ea1i t\u1ebf b\u00e0o, t\u1eeb t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u1ebfn t\u1ebf b\u00e0o c\u01a1… Continue reading L\u00e3o h\u00f3a t\u1ebf b\u00e0o trong m\u00e1u ti\u1ebft l\u1ed9 nguy c\u01a1 m\u1eafc b\u1ec7nh<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,2],"tags":[],"class_list":["post-17","post","type-post","status-publish","format-standard","hentry","category-nhan-dao-con-nguoi","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/posts\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":1,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/posts\/17\/revisions"}],"predecessor-version":[{"id":18,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/posts\/17\/revisions\/18"}],"wp:attachment":[{"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/media?parent=17"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/categories?post=17"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/crseh.com\/vi\/wp-json\/wp\/v2\/tags?post=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}